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We are seeking a talented and motivated Associate Scientific Director with experience in immuno-oncology and cancer vaccine development to move our novel shared antigen vaccine concepts to the clinic. The successful candidate will drive preclinical research efforts to support our cancer vaccine target selection and validation processes, evaluate rational vaccine drug combinations, measure human T cell responses to vaccine antigens, and generate complete IND-enabling proof-of-biology data sets. The successful candidate should have experience developing nucleic acid-based vaccines that target tumor antigens. They should have a track record of developing novel immune mono- and combination therapies to treat cancer. Here's What You'll Do Orchestrate the development of novel vaccine therapeutics from design, pre-clinical testing to IND-filing. Collaborate with other teams to evaluate and optimize cancer vaccine technologies. Determine preclinical in vitro and in vivo models for testing cancer vaccines. Generate complete data packages for IND filings. Lead and mentor a team of scientists, developing both managers and individual contributors. Present team findings at internal and external meetings in the form of scientific abstracts, posters, presentations, or manuscripts. Liaise and collaborate with internal and external research groups. Here's What You'll Need (Minimum Qualifications) PhD in biology, immunology, virology, or related areas of study Minimum of 7 years of experience in immune oncology and at least 5 years in the biotech/pharmaceutical industry. Here's What You'll Bring to the Table (Preferred Qualifications) A record of innovation and research accomplishments in translating cancer therapeutics from preclinical to clinic setting is required. You should possess extensive knowledge of vaccine biology, murine tumor models, immunological assays including in vitro/ex-vivo T cell activation and expansion, cytokine profiling, and immune cell characterization by flow cytometry. Experience developing mRNA-based cancer therapeutics in pre-clinical in vitro and in vivo models is preferred. Strong management experience including a history of developing reports at various levels is required. Familiarity with emergent and current standards of care to help define treatment settings, rational combinations, including with cancer vaccines to interrogate pre-clinically is a plus Capability to anticipate and recognize potential issues within experimental designs and effectively communicate alternatives Ability to effectively collaborate in a dynamic, cross-functional matrixed environment. Innovative, scientific versatility, flexibility, strong organizational skills, attention to detail. Ability to manage multiple projects in a fast-paced environment, prioritize work and meet tight timelines. Applicants should be highly collaborative team players, excellent communicators and have a demonstrable track record of research accomplishments. Respectful and inclusive attitude for your colleagues/team members, in addition to your exemplary collaborative nature, boldness, creativity, curiosity and relentlessness A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative. Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including: Highly competitive and inclusive medical, dental and vision coverage options Flexible Spending Accounts for medical expenses and dependent care expenses Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities Family care benefits, including subsidized back-up care options and on-demand tutoring Free premium access to fitness, nutrition, and mindfulness classes Exclusive preferred pricing on Peloton fitness equipment Adoption and family-planning benefits Dedicated care coordination support for our LGBTQ+ community Generous paid time off, including: Vacation, sick time and holidays Volunteer time to participate within your community Discretionary year-end shutdown Paid sabbatical after 5 years; every 3 years thereafter Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents 401k match and Financial Planning tools Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options Complimentary concierge service including home services research, travel booking, and entertainment requests Free parking or subsidized commuter passes Location-specific perks and extras! About Moderna Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Moderna is a smoke-free, alcohol-free and drug-free work environment. Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply! Moderna is proud to be an equal opportunity workplace and is an affirmative action employer. Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements. Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We're focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best. Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at leavesandaccommodations@modernatx.com. (EEO/AAP Employer) LI-MBB1 -", "stars": 0.0, "medallionProgram": null, "location_flexibility": null, "work_location_option": null, "canonicalPositionUrl": "https://modernatx.eightfold.ai/careers/job/309255560701", "isPrivate": false}, {"id": 309255560946, "name": "Sr. Research Associate, Cancer Vaccines Research", "location": "Cambridge, Massachusetts", "locations": ["Cambridge, Massachusetts"], "hot": 0, "department": "Research", "business_unit": "Stephen Hoge", "t_update": 1701550448, "t_create": 1694131200, "ats_job_id": "R14207", "display_job_id": "R14207", "type": "ATS", "id_locale": "R14207-en", "job_description": "Build novel platform technologies to support vaccine discovery and development Optimize primary human immune cell co-culture assays and performing all associated read-outs Independently plan experiments Perform data analysis, troubleshooting experiments, and recording results in electronic lab notebook. Contribute to reports, regulatory submissions and presentations Collaborate with multiple teams to achieve shared project goals Faithfully document scientific work and contribute to reports, presentations, and regulatory submissions Additional duties as might be assigned from time to time BA/BS degree Minimum of 3 years of experience working with primary immune cells and cell-based assays Experience performing immune assays on oncology patient samples strongly preferred. Expertise in cell-based immune assays Isolation of nucleic acids from cultured cells and harvested tissue. Protein quantification by Western, ELISA, MSD Applicants should be highly collaborative team players, excellent communicators and have a demonstrable track record of research accomplishments. A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative.", "stars": 0.0, "medallionProgram": null, "location_flexibility": null, "work_location_option": null, "canonicalPositionUrl": "https://modernatx.eightfold.ai/careers/job/309255560946", "isPrivate": false}, {"id": 309255475361, "name": "2024 Co-Op, Research, Biological Sciences", "location": "Cambridge, Massachusetts", "locations": ["Cambridge, Massachusetts"], "hot": 0, "department": "Campus Programs", "business_unit": "Unknown", "t_update": 1701550886, "t_create": 1693526400, "ats_job_id": "R14158", "display_job_id": "R14158", "type": "ATS", "id_locale": "R14158-en", "job_description": "Protein Science provides the opportunity to produce and characterize recombinant proteins, with the goal of expanding our understanding of the biology of mRNA therapeutics and improving their design and manufacture. Previous experience with recombinant protein expression and purification preferred. Cell Biology this is an opportunity to contribute to the development of our mRNA therapeutics platform and get cross-functional training in cell-based assay development and fluorescence microscopy techniques to investigate cellular uptake, subcellular distribution and intracellular trafficking kinetics of mRNA. Previous exposure to cell biology, cell culture and microscopy is preferred. Translational biology provides the opportunity to design and develop experimental capabilities that enable our understanding of LNP and mRNA related biology. As a co-op, you will participate in multitude of in vitro, ex vivo and in vivo experimental efforts that aid in the development of our next generation of mRNA and LNP therapeutics. Previous experience in molecular biology and/or bioengineering is preferred. Research Automation Specific projects will involve learning various types of biological assays that support the Research and Early Development (R&ED) and Oncology research organization. The co-op will support the Research Automation team through in vitro and in vivo screen efforts. Mentoring, opportunities to enhance critical thinking, flexibility, multitasking, attention to detail and training on Hamilton automation infrastructure will be provided to accomplish day-to-day activities. Currently enrolled Junior, Senior or Master's candidate Previous co-op or intern experience preferred Must have completed laboratory-intensive coursework in Chemistry, Biochemistry, Bioengineering, Molecular Biology, or similar discipline Familiarity with Molecular Biology preferred Previous mammalian cell culture experience preferred Must be eager, open to learning, independent and dedicated to high-quality science Minimum GPA of 3.4 preferred Legal authorization to work in the US", "stars": 0.0, "medallionProgram": null, "location_flexibility": null, "work_location_option": null, "canonicalPositionUrl": "https://modernatx.eightfold.ai/careers/job/309255475361", "isPrivate": false}, {"id": 309255475592, "name": "2024 Co-Op, Infectious Disease Research, Immunology", "location": "Cambridge, Massachusetts", "locations": ["Cambridge, Massachusetts"], "hot": 0, "department": "Campus Programs", "business_unit": "Unknown", "t_update": 1701550668, "t_create": 1693526400, "ats_job_id": "R14169", "display_job_id": "R14169", "type": "ATS", "id_locale": "R14169-en", "job_description": "The Role: The Moderna Research Co-op program is a 6-month experiential training program for students currently working towards an undergraduate or advanced degree in life sciences. During the co-op you will learn about the pharmaceutical and biotechnology industry and gain valuable hands-on experience in one of the most bold and relentless companies currently leading the field in mRNA-LNP science. You will work under the supervision of an experienced Moderna team member and have opportunities for cross-team collaboration, networking, and mentorship. You will develop laboratory skills and learn about lab safety, experimental design, scientific strategy, and record keeping. If you are bold, relentless, collaborative and obsess over learning, a co-op at Moderna will help augment your research experience and accelerate your career. Our winter/spring co-op program is from January 16 - June 14, 2024. All applicants must be available for the entire duration of the program. Here's What You'll Do: Infectious Diseases: Be part of the team responsible for advancing vaccine candidates from discovery to clinical trials and work within a specific focus within the Infectious Disease team in Immunology (Train and carryout immunoassays in preclinical settings such as flow cytometry, ELISAs, ELISPOT and their corresponding analysis) Bacterial Immunology Assist in the execution of bacterial and immunological assays to support the team's multiple immunotherapy programs. Assays may include OPKA, SBA, complement deposition, agglutination, etc. Here's What You'll Bring to the Table: Currently enrolled in an undergraduate or advanced degree program in biomedical sciences (Biology, Chemistry, Computational Biology, Biochemistry, Microbiology, Molecular Biology, Structural Biology), or bioengineering. Basic knowledge of basic lab procedures (such as pipetting) required. Technical experience in any of the following areas desired: cell/tissue culture, transfections, protein detection methods (e.g., MSD, ELISA, Luminex), molecular biology techniques (e.g., PCR, DNA/RNA extractions), cell characterization (e.g., flow cytometry), assay development and troubleshooting. Prior co-op or internship experience is preferred but not required. Self-motivated, enthusiastic, and possess the desire to drive a project to completion. Flexible and capable of working in a fast-paced, team-oriented environment. Legal authorization to work in the US. Moderna is pleased to provide you with an innovative suite of benefits, including: Free premium access to meditation and mindfulness classes Free parking or subsidized commuter passes Generous paid time off, including: Vacation, sick time and holidays Volunteer time to participate within your community Discretionary year-end shutdown Location-specific perks and extras! About Moderna Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Moderna is a smoke-free, alcohol-free and drug-free work environment. Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply! Moderna is proud to be an equal opportunity workplace and is an affirmative action employer. Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements. Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We're focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best. Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at leavesandaccommodations@modernatx.com. (EEO/AAP Employer) -", "stars": 0.0, "medallionProgram": null, "location_flexibility": null, "work_location_option": null, "canonicalPositionUrl": "https://modernatx.eightfold.ai/careers/job/309255475592", "isPrivate": false}, {"id": 309256517617, "name": "Sr. Research Associate (Non-PhD), Clinical Biomarker Laboratory, Immuno-Assays & Bio-Analytics", "location": "Cambridge, Massachusetts", "locations": ["Cambridge, Massachusetts"], "hot": 0, "department": "Clinical Development and Operations", "business_unit": "Stephen Hoge", "t_update": 1701549922, "t_create": 1698624000, "ats_job_id": "R14621", "display_job_id": "R14621", "type": "ATS", "id_locale": "R14621-en", "job_description": "As a key analyst, conduct assay development, qualification/validation and sample analysis on a variety of platforms (ELISA, MSD, Ella, Hamilton ) Deliver high quality data within defined timelines and aligned to current industry expectations Review and QC data, author bioanalytical reports Identify and resolve quality issues and report issues to upper management Bachelor or MSc with 2+ years' experience in bioanalysis or related field preferably in a regulated environment for biomarker analysis Demonstrated level of independence Flexibility with changing priorities and urgent project requests Good level of understanding and expertise in design and executing ligand binding based bioanalytical methods Knowledge in best practices recommended by FDA, CLSI to conduct development, qualification and validation of assays (e.g. M10 Bioanalytical Method Validation) Good written, presentation and interpersonal communication skills Good computational skills, preferably experienced with Word, Excel, Power Point, GraphPad Prism Knowledge of system software for data analysis: Softmax pro, Gen 5 and basic laboratory statistics Experience with LIMS system Understanding of current GLP or CAP/CLIA/ISO standards Preferably experienced with Multiplex immunoassay Preferably experienced with bioanalytical assays for vaccine development and infectious disease Preferably experienced with cell-based neutralization assay Preferably experienced with cell culture, ex vivo assays and cell isolation from tissues", "stars": 0.0, "medallionProgram": null, "location_flexibility": null, "work_location_option": null, "canonicalPositionUrl": "https://modernatx.eightfold.ai/careers/job/309256517617", "isPrivate": false}, {"id": 309256445006, "name": "Director, Rare Disease Research", "location": "Cambridge, Massachusetts", "locations": ["Cambridge, Massachusetts"], "hot": 0, "department": "Research", "business_unit": "Stephen Hoge", "t_update": 1701550516, "t_create": 1698019200, "ats_job_id": "R14595", "display_job_id": "R14595", "type": "ATS", "id_locale": "R14595-en", "job_description": "Lead efforts to develop mRNA-based therapies for rare diseases. Work to develop, improve, and optimize therapeutic targets for rare diseases. Lead a team of passionate scientists to accomplish departmental goals. Collaborate across Research organization to design proteins and optimize mRNA sequences. Design, plan, and Execute in vitro and in vivo experiments to select constructs, establish dose response relationships in animal models and cell culture systems. Communicate results clearly and concisely across the Rare Disease Research department and the organization. PhD in Biology, Biochemistry, Genetics, or equivalent field. Extensive experience in leading a team in an academic or industrial environment. Proven track record of design and development of strategies for characterizing and improving protein function or targeting. Experience in protein structure, biochemical techniques, and enzyme activity assays preferred. Demonstrated proficiency in people management including building, leading, and developing direct reports. Excellent interpersonal, verbal, and written communication skills. Strong desire to work in the Rare Disease space, implementing creative thinking to develop therapeutic targets for patients in need.", "stars": 0.0, "medallionProgram": null, "location_flexibility": null, "work_location_option": null, "canonicalPositionUrl": "https://modernatx.eightfold.ai/careers/job/309256445006", "isPrivate": false}, {"id": 309255603700, "name": "Associate Scientific Director, Novel Assay and Technology Development, Cancer Vaccines Research", "location": "Cambridge, Massachusetts", "locations": ["Cambridge, Massachusetts"], "hot": 0, "department": "Research", "business_unit": "Stephen Hoge", "t_update": 1701549756, "t_create": 1694131200, "ats_job_id": "R14206", "display_job_id": "R14206", "type": "ATS", "id_locale": "R14206-en", "job_description": "The successful candidate should have experience developing tumor antigen-targeting medicines from concept to the clinic. An extensive knowledge base in immunological assays that evaluate and deeply characterize T cell responses to antigens in vitro/ex-vivo T cell activation and expansion, cytokine profiling, and immune cell characterization by flow cytometry is required. The successful candidate should also be an expert in NGS, single cell sequencing, and other molecular biology-based technology development. Lead a team to build novel human primary cell- and molecular biology-based platform technologies to support personalized neoantigen vaccine antigen selection and validation, as well as develop novel ways of generating INTs Collaborate with multiple teams across Cancer Vaccine Platform, Bioinformatics, Immunopeptidomics, and Translational Medicine to test new technology approaches. Generate data packages for IND filings Lead and mentor a team of scientists, developing both managers and individual contributors Execute and troubleshoot standard protocols, adapt new protocols into practice with little assistance, and query literature to implement new assays as needed to query vaccine function and effectiveness Deliver reproducible and impactful results under ambitious timelines. Independently plan experiments Analyze, interpret and present data Faithfully document scientific work Present team findings at internal and external meetings in the form of scientific abstracts, posters, presentations, or manuscripts PhD in biology, immunology, virology, or related areas of study Minimum of 7 years of experience in immune oncology and at least 5 years in the biotech/pharmaceutical industry. Experience with nucleic acid-based vaccine technologies is preferred Multi-color flow cytometry; cell sorting; phenotyping murine, NHP and human immune cells Cell-based assays (e.g. ELISpot/ FluoroSpot, co-culture functional assays, live cell imaging, etc.) Ability to effectively collaborate in a dynamic, cross-functional matrixed environment Ability to manage multiple projects in a fast-paced environment, prioritize work and meet tight timelines", "stars": 0.0, "medallionProgram": null, "location_flexibility": null, "work_location_option": null, "canonicalPositionUrl": "https://modernatx.eightfold.ai/careers/job/309255603700", "isPrivate": false}, {"id": 309255545045, "name": "Sr. Director, Pulmonary Research", "location": "Cambridge, Massachusetts", "locations": ["Cambridge, Massachusetts"], "hot": 0, "department": "Research", "business_unit": "Stephen Hoge", "t_update": 1701550396, "t_create": 1694131200, "ats_job_id": "R14197", "display_job_id": "R14197", "type": "ATS", "id_locale": "R14197-en", "job_description": "Build and establish internal pulmonary capabilities and expertise to enable the inhaled pulmonary modality and therapeutics area Lead and direct a range of internal pulmonary therapeutic research projects. Define objectives for research projects and ensure high-quality execution of these projects, including oversight of assays, study designs, and data Advance pulmonary therapeutic research projects into early development Oversee and manage relationships with external partners and collaborators. Serve as Program Lead for external collaboration, effectively managing a large cross-functional internal team and working closely with external stakeholders to scientifically direct collaborations Mentor and have direct management responsibilities for the pulmonary research team Stay up-to-date with the latest scientific advances in pulmonary research and identify opportunities to incorporate new research methods and technologies Promote cross-functional collaboration across the organization Effectively communicate research progress, challenges and results to a variety of stakeholders, including teams across R&D organizations Ph.D. and/or MD in pulmonary pharmacology, respiratory medicine or related field with 14+ years of relevant experience in pulmonary research in industry setting Strong pulmonary physiology and pharmacology experience with direct experience with nebulized delivery of drug product Strong track record driving discovery projects into early development and leading successful research teams and projects Proven ability to oversee and manage strategic partnerships and collaborations Deep understanding of the scientific aspects of drug discovery and development Excellent leadership and team building skills Strong written and oral communication skills scaling through all levels of the organization, including senior management Strong leadership skills and an ability to collaborate productively across multiple cross-functional project teams are paramount. Ability to thrive in a fast paced environment; ability to adapt to changes with demonstrated flexibility to pivot as warranted and needed Acts with urgency with the understanding that actions today compounds lives saved tomorrow Acts like an owner, obsesses over learning, questions convention and strives to push past possible Scientific rigor & commitment to excellence and innovation.", "stars": 0.0, "medallionProgram": null, "location_flexibility": null, "work_location_option": null, "canonicalPositionUrl": "https://modernatx.eightfold.ai/careers/job/309255545045", "isPrivate": false}, {"id": 309255475282, "name": "2024 Co-Op, Infectious Disease Research, Antigen Design & Selection", "location": "Norwood, Massachusetts", "locations": ["Norwood, Massachusetts"], "hot": 0, "department": "Campus Programs", "business_unit": "Unknown", "t_update": 1701550602, "t_create": 1693526400, "ats_job_id": "R14155", "display_job_id": "R14155", "type": "ATS", "id_locale": "R14155-en", "job_description": "Infectious Diseases: Be part of the team responsible for advancing vaccine candidates from discovery to clinical trials and work within a specific focus within the Infectious Disease team on, Antigen Design & Selection: The overarching goal of Antigen Design & Selection is to rationally design and select antigen variants that have the highest chance of success in clinical trials. This overall goal can be achieved by combining the powers of 1) Structural biology and structure-based antigen design, 2) Protein production and purification, 3) Antigen screening and characterization, and 4) Bioinformatics analysis and computation-aided designs. We are seeking co-ops to have direct exposure to Structure Biology and Antigen screening and characterization. With guidance, execute protein and cell-based assays (Flow cytometry, SDS-PAGE, Western Blot Culture mammalian cell lines for downstream applications Collaborate with direct team members to translate and transition new assays (cellular, biochemical, and biophysical) to an automated platform. Collaborate with direct team members to optimize existing automated workflows Utilize an ELN to capture experimental results and participate in LIMS integration. Assist in reagent ordering and inventory and design of new automation equipment. Currently enrolled in an undergraduate or advanced degree program in biomedical sciences (Biology, Chemistry, Computational Biology, Biochemistry, Microbiology, Molecular Biology, Structural Biology), or bioengineering or similar. Basic knowledge of basic lab procedures (such as pipetting) required Technical experience in any of the following areas desired: cell/tissue culture, transfections, protein purification (affinity chromatography and size-exclusion chromatography), protein analytics (SDS-PAGE), protein detection methods (e.g., MSD, ELISA), molecular biology techniques (e.g., PCR, DNA/RNA extractions), cell characterization (e.g., flow cytometry), assay development and troubleshooting, structural biology methodologies (x-ray crystallography and electron microscopy). Prior co-op or internship experience is preferred but not required Self-motivated, enthusiastic, and possess the desire to drive a project to completion. Flexible and capable of working in a fast-paced, team-oriented environment. Legal authorization to work in the US", "stars": 0.0, "medallionProgram": null, "location_flexibility": null, "work_location_option": null, "canonicalPositionUrl": "https://modernatx.eightfold.ai/careers/job/309255475282", "isPrivate": false}, {"id": 309255435272, "name": "Principal Research Associate, Nucleic Acid Chemistry", "location": "Cambridge, Massachusetts", "locations": ["Cambridge, Massachusetts"], "hot": 0, "department": "Research", "business_unit": "Stephen Hoge", "t_update": 1701549806, "t_create": 1693353600, "ats_job_id": "R13963", "display_job_id": "R13963", "type": "ATS", "id_locale": "R13963-en", "job_description": "The Role As part of our vision, Moderna is committed to invest in R&D to further expand our impact on patients. We are building an independent research and business unit for genomic medicines, called Moderna Genomics (mGx) based in Technology Square, Cambridge, MA. mGx will be an innovation engine for the company focused on discovering and delivering the next generation of in vivo gene editing and nonviral gene therapies. Moderna Genomics strives to be an industry leader in genomic medicines. Within Moderna Genomics, the Gene Editing Innovation (GEI) team seeks a skilled, enthusiastic, and highly motivated Principal Research Associate to contribute to our initiatives to leverage chemical innovation for gene editing. The goal is to integrate synthetic chemistry, chemically modified nucleic acids and proteins to deliver the best-in-class gene-editing and gene-delivery system, implemented with Moderna's powerful mRNA platform. The candidate will focus on applying their expertise in nucleic acid chemistry to develop Moderna's next generation in vivo gene editing and nonviral gene therapies. The candidate will design experiments, develop the appropriate chemistry methods, and perform in vitro as well as cell-based assays to study and characterize gene-editing systems and novel drug delivery methods. As a member of this cross-functional group, the candidate will also have a rare opportunity to work collaboratively with Scientists within the Moderna Genomics unit and across the Moderna ecosystem, such as RNA science. This role will have the unique opportunity to make an impact as an early member of the Chemical Innovation team within GEI, enabling key mGx gene editing efforts and shaping the team and culture for this exciting initiative. Here's What You'll Do Design, synthesize, and validate novel guide nucleic acids in gene editing systems using expertise in chemical biology, solid phase synthesis, mammalian cell culture, and molecular biology Perform biochemical assays not limited to gel electrophoresis, PCR, fragment analysis, and chromatography Perform cell culture, including maintenance and manipulation of cell lines Maintain clear and detailed electronic notebook Work well in a collaborative environment Present results at internal meetings Here's What You'll Need (Minimum Qualifications) A Bachelor's degree in chemical biology, biochemistry, molecular biology, chemistry, or related science and a minimum 5 years years' of relevant industry or academic experience. (Master's degree and minimum 3 years' of relevant industry or academic experience. Hands-on experience with mammalian cell culture Here's What You'll Bring to the Table (Preferred Qualifications) Experience characterizing nucleic acid therapeutics Expertise in the biochemical characterization of nucleic acids including gel electrophoresis, capillary electrophoresis, and PCR Experience with enzymatic manipulation of nucleic acids Ability to learn quickly and work in a highly collaborative environment Knowledge of gene-editing technologies, solid phase oligonucleotide synthesis, and mass spectrometry is a plus. Excellent written and verbal communication skills A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative. Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including: Highly competitive and inclusive medical, dental and vision coverage options Flexible Spending Accounts for medical expenses and dependent care expenses Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities Family care benefits, including subsidized back-up care options and on-demand tutoring Free premium access to fitness, nutrition, and mindfulness classes Exclusive preferred pricing on Peloton fitness equipment Adoption and family-planning benefits Dedicated care coordination support for our LGBTQ+ community Generous paid time off, including: Vacation, sick time and holidays Volunteer time to participate within your community Discretionary year-end shutdown Paid sabbatical after 5 years; every 3 years thereafter Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents 401k match and Financial Planning tools Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options Complimentary concierge service including home services research, travel booking, and entertainment requests Free parking or subsidized commuter passes Location-specific perks and extras! About Moderna Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Moderna is a smoke-free, alcohol-free and drug-free work environment. Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply! Moderna is proud to be an equal opportunity workplace and is an affirmative action employer. Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements. Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We're focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best. Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at leavesandaccommodations@modernatx.com. 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